Conference Abstracts and Non-Peer Reviewed Papers

1. Kosow, D.P., Esnouf, M.P., Gainey, A., Hill, H.A.O. and Thornalley, P.J. (1981) Vitamin-K dependent carboxylation of peptide bound glutamic acid residues. Thrombosis & Haemostasis 46, 120 (Abstract).

2. Hooper, N.I., Tisdale, M.J. and Thornalley, P.J. (1987) Changes in glyoxalase activities during differentiation of human leukaemia cells in vitro. Cell Differentiation 20, Suppl. 1, 885 (Abstract).

3. Hooper, N.I., Catterall, L.M., Thornalley, P.J., Jones, A.F., Lunec, J., Jennings, P.E. and Barnett, A.H. (1987) The red blood cell glyoxalase system in diabetic patients and hyperglycaemia in vitro. Diabetic Medicine 4, 375 (Abstract).

4. Smith, P.R., Saeed, S., Selwood, T. and Thornalley, P.J. (1992) Pharmacological intervention to prevent the development of diabetic complications. Diabetic Medicine 9, Suppl. 1, 20A (Abstract).

5. M^cLellan, A.C., Thornalley, P.J. and Benn, J. (1992) Modification of the red blood cell glyoxalase system in clinical diabetes mellitus, Diabetic Medicine 9, Suppl. 1, 20A (Abstract).

6. Clelland, J.D., Edwards, L.G., Allen, R.E. and Thornalley, P.J. (1993) Inhibition of growth of human leukaemia 60 cells by S-2-hydroxyacylglutathione derivatives. Biochem. Soc. Trans. 21, 165S.

7. Edwards, L.G., Clelland, J.D. and Thornalley, P.J. (1993) Mechanism of the inhibition of growth of human leukaemia 60 cells by S-D-lactoylglutathione. Biochem. Soc. Trans. 21, 166S.

8. Ayoub, F.M., Zaman, M.A., Thornalley, P.J. and Masters, J.R.W. (1993) Glyoxalase activities in human tumour cell lines in vitro. Biochem. Soc. Trans. 21, 167S.

9. Ayoub, F.M., Allen, R.E. and Thornalley, P.J. (1993) Inhibition of proliferation of human leukaemia 60 cells by methylglyoxal in vitro. Biochem. Soc. Trans. 21, 168S.

10. Phillips, S.A., Mirrlees, D. and Thornalley, P.J. (1993) Modification of the glyoxalase system in streptozotocin-induced diabetic rats and the effects of the aldose reductase inhibitor Statil. Biochem. Soc. Trans. 21, 162S.

11. Reeves, M.E. and Thornalley, P.J. (1993) The hydrolysis of S-D-lactoylglutathione. Biochem. Soc. Trans. 21, 169S.

12. Phillips, S.A. and Thornalley, P.J. (1993) Formation of methylglyoxal and D-lactate in human red blood cells in vitro. Biochem. Soc. Trans. 21, 163S.

13. M^cLellan, A.C., Phillips, S.A. and Thornalley, P.J. (1993) The assay of S-D-lactoylglutathione in biological systems. Biochem. Soc. Trans. 21, 164S.

14. Allen, R.E. and Thornalley, P.J. (1993) The effect of S-D-lactoylglutathione on the chemotaxis of human neutrophils. Biochem. Soc. Trans. 21, 161S.

15. Clelland, J.D. and Thornalley, P.J. (1993) Potentiation of GTP-dependent microtubule assembly by S-D-lactoylglutathione. Biochem. Soc. Trans. 21, 160S.

16. Lo, T.W.C. and Thornalley, P.J. (1993) Inhibition of human leukaemia 60 cell growth by diethyl esterification of the glyoxalase II inhibitor S-p-nitrobenzoxycarbonylglutathione in vitro. Biochem. Soc. Trans. 21, 159S.

17. M^cLellan, A.C., Thornalley, P.J., Benn, J. and Sönksen, P.H. (1993) Modification of the glyoxalase system in clinical diabetes mellitus. Biochem. Soc. Trans. 21, 158S.

18. M^cLellan, A.C., Thornalley, P.J., Benn, J. and Sönksen, P.H. (1993) Population genetics of human glyoxalases and the development of diabetic complications. Biochem. Soc. Trans. 21, 172S.

19. Allen, R.E. and Thornalley, P.J. (1993) Simple chromatographic methods for the purification of human red blood cell glyoxalase I and glyoxalase II to homogeneity. Biochem. Soc. Trans. 21, 171S.

20. Selwood, T. and Thornalley, P.J. (1993) Binding of methylglyoxal to albumin and formation of fluorescent adducts. Inhibition by arginine, N_α-acetylarginine and aminoguanidine. Biochem. Soc. Trans. 21, 170S.

21. Thornalley, P.J. (1993) Modification of the glyoxalase system in disease processes and prospects for therapeutic strategies. Biochem. Soc. Trans. 21, 531-534.

22. Allen, R.E., Lo, T.W.C. and Thornalley, P.J. (1993) Inhibitors of glyoxalase I: design, synthesis, inhibitory characteristics and biological evaluation. Biochem. Soc. Trans. 21, 535-540.

23. Lo, T.W.C., Selwood, T. and Thornalley, P.J. (1993) Modification of plasma protein by methylglyoxal under physiological conditions. Prevention by aminoguanidine and L-arginine. Amino Acids 5, 172 (Abstract).

24. Thornalley, P.J., Edwards, L.G., Adesida, A. & Double, J. (1995) Novel anti-tumour agents designed from the glyoxalase system. Proc. Amer. Soc. Cancer Res. 36, 386 (Abstract).

25. M^cLellan, A.C., Thornalley, P.J., Benn, J. and Sonksen, P.H. (1995) Methylglyoxal metabolism and the development of diabetic complications. Diabetic Med. 12, Suppl. 2-10, p. S48 (Abstract).

26. Westwood, M.E. and Thornalley P.J. (1995) Cytokine synthesis and secretion induced by methylglyoxal-modified proteins. Diabet. Med. 12, Suppl. 2-10, p. S49 (Abstract).

27. Kang, Y. and Thornalley, P.J. (1996) Mechanism of apoptosis induced by methylglyoxal and the glyoxalase I inhibitor prodrug, S-p-bromobenzylglutathione cyclopentyl diester. Proc. Amer. Soc Cancer Res. 37, 24 (Abstract).
    
28. Thornalley,P.J., M^cLellan, A.C., Lo, T.W.C., Benn, J. and Sönksen, P.H. (1996) Increased concentrations of glyoxal and methylglyoxal in blood samples of IDDM patients, relative to age- and sex-matched normal healthy human subjects. Diabetes 45, Suppl. 2, 270A (Abstract).

29. Abordo, E., Argirov, O.K. and Thornalley, P.J. (1996) Human serum albumin minimally-modified by methylglyoxal but not by glucose-derived advanced glycation endproducts induced the synthesis and secretion of tumour necrosis factor-α (TNF-α) by human monocytic THP-1 cells in vitro. Diabetes 45, Suppl. 2, 129A (Abstract).

30. Webster, L., Abordo, E.A., Thornalley, P.J. and Limb, G.A. (1996) Induction of TNFα and IL-1β mRNA in monocytes by methylglyoxal- and AGE-modified human serum albumin. Immunology 89, Suppl. 1, 58 (Abstract).

31. Eriksson, U.J., Wentzel, P., Minhas, H.S. and Thornalley, P.J. (1997) High 3-Deoxyglucosone (3-DG) concentration in malformed rat embryos in vitro. Diabetologia 40, S1, A233 (Abstract)

32. Webster L, Abordo EA, Thornalley PJ, Limb GA (1997) Induction of TNF alpha and IL-1 beta mRNA in monocytes by methylglyoxal- and advanced glycated endproduct-modified human serum albumin. Biochem. Soc. Trans. 25, S250-S250.

33. Thornalley, P.J., Argirov, O.K., Cordeiro, C.A. and Haik Jr, G.M. (1998) Molecular mass changes of serum albumin of diabetic patients with and without retinopathy indicate minimal extent of serum albumin glycation in vivo. Diabetes 47, Suppl. 1, A428 (Abstract).

34. Giardino, I., Thornalley, P.J., Edelstein, D. and Brownlee, M. (1998) Generation and characterisation of an antibody against AGEs that induce endothelial dysfunction. Diabetes 47, Suppl. 1, A123 (Abstract).

35. Nagai, R., Thornalley, P.J., Jono, T. and Horiuchi, S. (1999) Detection of N^ε(carboxyethyl)lysine in glucose-modified AGE-proteins: implication of an important role of methylglyoxal as an active intermediate for AGE-formation. Diabetes 48, Suppl. 1, 135. (Abstract).

36. Millar, D.J., Thornalley, P.J. and Dawnay, A. (1999) In vitro advanced glycation end product formation with methylglyoxal – a glucose breakdown product in uraemic and diabetic sera and peritoneal dialysis fluid. Kidney Internat. 55, 2575 (Abstract).

37. Mann, V.M., Tucker, B., Thornalley, P.J. and Dawnay, A. (1999) Elevated serum methylglyoxal and glyoxal in uraemia: implications for advanced glycation endproduct formation. Kidney Internat. 55, 2582. (Abstract).

38. Xu, K. and Thornalley, P.J. (1999) Inhibition of leukaemia growth and apoptosis induced by phenethyl isothiocyanate and cysteine conjugate. British Journal of Cancer 81, 574-575. (Abstract).

39. Dawnay, A., Argirova, M., Millar D. J., Holmes, C. and Thornalley, P. J. (1999) Reduction of dicarbonyl compounds in a novel peritoneal dialysis solution. J. Am. Soc. Nephrol. 10, 312A-312A. (Abstract).

40. Millar, D.J., Thornalley, P. J. and Dawnay A. (1999) In vitro advanced glycation end products (AGE) formation with glyoxal and 3-deoxyglucosone – glucose derived products in uraemic sera and PD fluid. J. Am. Soc. Nephrol. 10, 318A-318A. (Abstract).

41. Thornalley, P.J., Jahan, I. and Ng, R. (2000) Prevention of triosephosphate accumulation and metabolism linked to complications in hyperglycaemia by thiamine. Diabetic Medicine 17, Suppl. 1, 37. (Abstract).

42. Abordo, E.A., Ahmed, N., Limb, G.A., Argirov, O.K. and Thornalley, P.J. (2000) Increased plasma protein methylglyoxal-derived advanced glycation endproducts in IDDM subjects with retinopathy. Diabetic Medicine 17, Suppl. 1, 33. (Abstract).

43. Xu, K. and Thornalley, P.J. (2000) Modification of glutathione and protein thiols in the initiation of HL60 cells by the cancer chemopreventive agent phenethyl isothiocyanate in vitro. Proc. Amer. Soc Cancer Res. 41, 660 (Abstract).

44. Thornalley, P.J., Jahan, I., Ahmed, N. and Ng, R. (2000) The putative antiglycation agent phenacylthiazolium bromide suppresses cellular triosephosphate accumulation in model hyperglycaemia in vitro by stimulating the pentosephosphate pathway to consume glyceraldehyde-3-phosphate and produce ribose-5-phosphate. Diabetes 49, Suppl. 1, A150

45. Matsumara, T., Edelstein, D., Hammes, H.-P., Thornalley, P.J. and Brownlee, M. (2000) Hyperglycaemia increases angiopoietin-2 expression in retinal Muller cells through superoxide-induced overproduction of α-oxoaldehyde AGE. Diabetes 49, Suppl. 1, A55.

46. Kilhovd, B.K., Giardino, I., Torjesen, P.A., Birkeland, K.I., Thornalley, P.J., Brownlee, M. and Hanssen, K.F. (2000) Increased serum methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes. Diabetologia 43, Suppl. 1, 210.

47. Limb, G.A., Zaman, A., Blood, I., Thornalley, P.J., Khaw, P.T., Luthert, P.J. and Charteris, D.G. (2000) Effect of methylglyoxal modified proteins on MMP and TIMP production by retinal pigment epithelial cells. Investigative Ophthalmology & Vis. Sci. 41, Suppl. S, 2160B406.

48. Ahmed, N. and Thornalley, P.J. (2000) Advanced glycation endproducts in serum albumin glycated by methylglyoxal and glucose in vitro. Endocrinol & Diabetes 108, A1-A2.

49. Thornalley, P.J., Wentzel, P., Karachalias, N. and Eriksson, U.J. (2001) Methylglyoxal is less teratogenic than 3-deoxyglucosone due to rapid metabolism in embryos exposed to high glucose concentration in vitro. Diabetologia 44, Suppl. 1, A12 (Abstract)

50. Ahmed, N., Thornalley, P.J., Franke, S, Stein, G. and Dawczynski, J. (2001) Fluorescent advanced glycation endproducts, argpyrimidine and pentosidine, in lens proteins of diabetic and healthy control human subjects. Diabetologia 44, Suppl. 1, A34 (Abstract)

51. Ahmed, N., Haik, G.M. Jr. and Thornalley, P.J. (2002) Hemoglobin glycated by methylglyoxal AGE-Hb_MG-H1 in type 1 diabetic subjects and relation to glycemic control. Diabetes 51, Suppl. 2, A118 (Abstract)

52. Babaei-Jadidi, R., Karachalias, N. and Thornalley, P.J. (2002) Prevention of nephropathy in streptozotocin-induced diabetic rats by thiamine. Diabetes 51, Suppl. 2, A183 (Abstract)

53. Ng, R., Argirov, O.K., Ahmed, N., Weigle, B. and Thornalley, P.J. (2002) Human serum albumin minimally modified by methylglyoxal binds to human mononuclear leukocytes via the RAGE receptor and is displaced by N_ε-carboxymethyl-lysine and hydroimidazolone AGE epitopes. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 77-81.

54. Agalou, S., Karachalias, N., Dawnay, A.B. and Thornalley, P.J. (2002) Reaction kinetics of the scavenging of α-oxoaldehydes by aminoguanidine under physiological conditions. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 513-515.

55. Agalou, S., Karachalias, N., Thornalley, P.J., Tucker, B.M. and Dawnay, A.B. (2002) Estimation of α-oxoaldehydes formed from the degradation of glycolytic intermediates and glucose fragmentation in blood plasma of human subjects with uraemia. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 181-182.

56. Battah, S., Ahmed, N. and Thornalley, P.J. (2002) Kinetics and mechanism of the reaction of metformin with methylglyoxal. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 255-356.

57. Battah, S., Ahmed, N. and Thornalley, P.J. (2002) Novel anti-glycation therapeutic agents: glyoxalase I mimetics. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 107-111.

58. Ahmed, N. and Thornalley, P.J. (2002) Assay of early and advanced glycation endproducts by enzymatic hydrolysis of proteins and HPLC of 6-quinolylaminiocarbonyl (AQC) adducts. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 279-283.

59. Jono,T., Nagai, R., Miyazaki, K., Ahmed, N., Thornalley, P.J., Kitamura, T. and Horiuchi,S. (2002) Detection of 3-deoxyglucosone-derived AGE structures in vivo. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 239-242.

60. Millar, D.J., Taylor, G.W., Thornalley, P.J., Holmes, C. and Dawnay, A. (2002) Comparison of in vitro protein modification with advanced glycation end product (AGE) precursors methylglyoxal, glyoxal, 3-deoxyglucosone and glucose using mass spectrometry. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 353-354.

61. Millar, D.J., Thornalley, P.J. and Dawnay, A. (2002) In vitro kinetics of AGE formation with PD fluid resembles that of glucose degradation products (GDPs) rather than glucose. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 475-477.

62. Agalou, S., Karachalias, N., Thornalley, P.J., Tucker, B.M. and Dawnay, A.B. (2002) Plasma protein-bound and free hydroimidazolone AGEs derived from methylglyoxal and 3-deoxyglucosone are elevated in dialysis patients compared with CML and pentosidine. J. Am. Soc. Nephrol. 14, 228A (Abstract).

63. Babaei-Jadidi, R., Karachalias, N. and Thornalley, P.J. (2003) Prevention of nephropathy in streptozotocin-induced diabetic rats by Benfotiamine. Diabetes 52, Suppl. 1, A481

64. Ahmed, N., Thornalley, P.J., Howell, S.K. and Beisswenger, P.J. (2003) Effect of Postprandial hyperglycemia on advanced glycation endproducts. Diabetes 52, Suppl. 1, A441

65. Ahmed, N.M., Portero-Otin, Manuel, Haik Jr., G.M. and Thornalley, P.J. (2003) Methylglyoxal and methylglyoxal-derived advanced glycation endproducts of hemoglobin in type 1 diabetes with and without retinopathy. Diabetes 52, Suppl. 1, A198

66. Karachalias, N., Babaei-Jadidi, R., Ahmed, N. and Thornalley, P.J. (2003) Quantitative comprehensive screening of advanced glycation endproducts reveals the selective accumulation of hydroimidazolone AGEs in the diabetic retina Diabetes 52, Suppl. 1, 23-LB

67. Lucas, A.J., Karachalias, N., Ahmed, N. and Thornalley, P.J. (2003) High concentrations of advanced glycation endproducts in cellular protein. http://www.biochemistry.org/meetings/abstracts/679/6790g14.pdf

68. Amajuoyi, I.K., Ahmed, N., Watts, R. and Thornalley, P.J. (2003) High levels of free advanced glycation endproducts in synovial fluid in arthritis. http://www.biochemistry.org/meetings/abstracts/679/6790g23.pdf

69. Ahmed, N., Hou, Y. and Thornalley, P.J. (2003) Peptide mapping of human serum albumin modified minimally by methylglyoxal. 
    http://www.biochemistry.org/meetings/abstracts/679/67900g2.pdf

70. Ahmed, N., Battah, S., Karachalias, N., Babaei-Jadidi, R., Horányi, M., Baróti, M., Hollan, S., and Thornalley, P.J. (2003) Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency. http://www.biochemistry.org/meetings/abstracts/679/67900g3.pdf

71. Thornalley, P.J., Babaei-Jadidi, R. and Karachalias, N. (2003) Prevention of incipient nephropathy by high dose thiamine and Benfotiamine in streptozotocin-induced diabetic rats with maintenance insulin therapy. Diabetologia 46, Suppl. 2, A345-A346 (Abstract)

72. Karachalias, N., Babaei-Jadidi, R., Ahmed, N.M., Battah, S. and Thornalley, P.J. (2003) High dose thiamine therapy suppresses the accumulation of advanced glycation endproducts and oxidative biomarkers in the glomeruli of streptozotocin-induced diabetic rats on insulin maintenance therapy. Diabetologia 46, Suppl. 2, A405 (Abstract)

73. Ahmed, N.M., Portero-Otin, Manuel, Haik Jr., G.M. and Thornalley, P.J. (2003) Oxidative markers in plasma protein and hemoglobin subjects with type 1 diabetes with and without background and proliferative retinopathy. Diabetes Metab. 29, 4S344 (Abstract)

74. Babaei-Jadidi, R., Karachalias, N. and Thornalley, P.J. (2003) High dose thiamine therapy suppresses the activation of protein kinase C_β in the glomeruli of streptozotocin-induced diabetic rats on insulin maintenance therapy. Diabetologia 46, Suppl. 2, A345 (Abstract)

75. Thornalley, P.J. (2003) The enzymatic defence against glycation in health, disease and therapeutics: a symposium to examine the concept. Biochem. Soc. Trans. 31, 1341–1342.

76. Thornalley, P.J. (2003) Glyoxalase I – structure, function and role in the enzymatic defence against glycation. Biochem. Soc. Trans. 31, 1343–1348.

77. Ahmed, N. and Thornalley, P.J. (2003) Application of LC-MS/MS for the quantitation of glycation, oxidation and nitrosation adducts. Biochem. Soc. Trans. 31, 1417–1422.

78. Karachalias, N., Babaei-Jadidi, R., Ahmed, N. and Thornalley, P.J. (2003) Accumulation of fructosyl-lysine and advanced glycation endproducts in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem. Soc. Trans.31, 1423-1425

79. Thornalley, P.J. Protecting the genome: defence against nucleotide glycation and emerging role in multidrug resistance in cancer chemotherapy. (2003) Biochem Soc. Trans. 31, 1372–1377.

80. Agalou, S., Ahmed, N., A. Dawnay and Thornalley, P.J. (2003) Removal of advanced glycation end products in clinical renal failure by peritoneal dialysis and haemodialysis. Biochem. Soc. Trans. 31, 1394–1396.

81. Morcos, M., Sayed, A., Pfisteer, F., Hutter, H., Thornalley, P., Ahmed, N., Miftan, N., Muhrlen, F., Hamman, A., Bierhaus, A. and Nawroth, P. (2004) Glyoxalase-I als endogener schutz vor advanced glycation end producy (AGE) formation und oxidativen stress in Caenorhabditis elegans. Diabetes und Stoffwechsel 13, 33 (abstract).

82. Thornalley, P.J., Kupich, C., Babaei-Jadidi, R., Karachalias, N. and Ahmed, N. (2004) Thiamine dose thiamine counters diabetic dyslipidemia. Diabetologia 47, suppl. 1, A413.

83. Song, L., Moore, M., Imbasi, P. and Thornalley, P.J. (2004) Inhibition of malignant and non-malignant cell growth by seven major dietary isothiocyanates in vitro. Cancer Epidemiology Biomarkers & Prevention 13, 1842S-1843S.

84. Babaei-Jadidi, R., Karachalias, N., Ahmed, N. and Thornalley, P.J. (2005) Reversal of metabolic dysfunction of human mesangial cells in hyperglycaemia in vitro by thiamine and Benfotiamine. Diabetic Med. 22, Suppl. 2, 22.

85. Karachalias, N., Babaei-Jadidi, R., Ahmed, N., Baynes, K. and Thornalley, P.J. (2005) Urinary D-lactate as a marker of biochemical dysfunction linked to the development of diabetic microvascular complications. Diabetic Med. 22, Suppl. 2, 21.

86. Ahmed, N._, Babaei-Jadidi, R., Howell, S.K., Thornalley, P.J. and Beisswenger, P.J. (2005) Dicarbonyl derived AGEs are decreased by reducing postprandial glucose levels. Diabetes 54, Suppl. 1, A513.

87. Thornalley, P.J. (2005) Protein damage by glycation, oxidation and nitrosation in diabetes. Free Radical Res. 39, Suppl. 1, S25.

88. Morcos, M., Du, X., Sayed, A.A.R., Hutter, H., Pfisterer, F., Thornalley, P.J., Baynes, J., Thorpe, S., Abd El Baki, R., Ahmed, N., Miftari, N., Stern, D., Schlotterer, A., Möhrlen, F., Hamann, A., Becker, C., Humpert, P., Hammes, H.P., Büchler, M., Bierhaus, A., Brownlee, M., Nawroth P.P. (2005) Life extension in Caenorhabditis elegans by overexpression of Glyoxalase I – the connection to protein damage by glycation, oxidation and nitration. Free Radical Res. 39, Suppl. 1, S43.

89. Ahmed, N., Babaei-Jadidi, R, Howell, S.K., Beisswenger, P. and Thornalley, P.J. (2005) Nitrosation of plasma protein and haemoglobin in type 1 diabetes – evidence for compartmentalized action of peroxynitrite in blood physiologically. Free Radical Res. 39, Suppl. 1, S81.

90. Babaei-Jadidi, R., Karachalias, N., Ahmed, N. and Thornalley, P.J. (2005) Prevention of incipient nephropathy by high dose thiamine and Benfotiamine in streptozotocin-induced diabetic rats: effect on markers of oxidative stress. Free Radical Res. 39, Suppl. 1, S81.

91. Imbasi, P., Song, L. and Thornalley, P.J. (2005) Induction of quinone reductase in human hepatoma HepG2 cells in vitro by dietary isothiocyanates: comparison of potency. Free Radical Res. 39, Suppl. 1, S81.

92. Song, L., Ahmed, N. and Thornalley, P.J. (2005) Concentrations of dietary isothiocyanates in plasma after consumption of raw broccoli by healthy human subjects. Free Radical Res. 39, Suppl. 1, S87.

93. Chen, Y., Ahmed, N. and Thornalley, P.J. (2005) Peptide mapping of human hemoglobin modified minimally by methylglyoxal in vitro. Ann. N.Y. Acad. Sci. 1043, 905.

94. Dobler, D., Ahmed, N. and Thornalley, P.J. (2005) Peptide mapping of type IV collagen modified minimally by methylglyoxal in vitro. Ann. N.Y. Acad. Sci. 1043, 906.

95. Agalou, S., Ahmed, N., Dawnay, A. and Thornalley, P.J. (2005) Advanced glycation endproduct excretion rates by peritoneal dialysis in end stage renal disease. Ann. N.Y. Acad. Sci. 1043, 921.

96. Ahmed, N., Babaei-Jadidi, R., Thornalley, P.J., Howell, S.K. and Beisswenger, P.J. (2005) Increased plasma and urinary methylglyoxal-derived hydroimidazolone in type 1 diabetic patients. Ann. N.Y. Acad. Sci. 1043, 928.

97. Ahmed, N., Ahmed, U., Hager, K., Fleischer, G., Münch, G. and Thornalley, P.J. (2005) Protein glycation marker residues and free adducts of cerebrospinal fluid in Alzheimer’s disease and link to cognitive impairment. Ann. N.Y. Acad. Sci. 1043, 914.

98. Kennish, L., Dobler, D., Ahmed, N. and Thornalley, P.J. (2005) Protein glycation and oxidation in cola and pasteurised milk. Ann. N.Y. Sci. 1043, 907.

99. Berlanga, J., Cibrian, D., Guillén, I., Freyre, F., Alba, J.S., Merino, N., Aldama, A., Quintela, A.M., Triana, M.E., Ajameich, H., Lopez, P., Ahmed, N. and Thornalley, P.J. (2005) Exogenous methylglyoxal induces diabetes-like microvascular changes in rats. Ann. N.Y. Acad. Sci. 1043, 918.

100. Agalou, S, Ahmed, N, Thornalley, P.J. and Dawnay, A. (2005) Advanced glycation endproduct free adducts are cleared by dialysis. Ann. N.Y. Acad. Sci. 1043, 922.

101. Ahmed, N., Karachalias, N., Babaei-Jadidi, R., Thornalley, P.J. (2005) Degradation products of proteins damaged by glycation and oxidation increase markedly in experimental diabetes and are suppressed by high dose therapy with thiamine and Benfotiamine. Diabetologia 48, Suppl. 1, A417 – A418

102. Thornalley, P.J. and Babaei-Jadidi, R. (2005) Prevention of microvascular complications of diabetes by high dose S-benzoylthiamine monophosphate (Benfotiamine): mechanism of thiamine delivery into cells. Diabetologia 48, Suppl. 1, A377.

103. Dobler, D., Ahmed, N. and Thornalley, P.J. (2005) Peptide mapping of type IV collagen modified minimally by methylglyoxal in vitro reveals mechanism of cell-matrix disruption. Internat. J. Exp. Pathol. 86, A83-A84

104. Ahmed, N., Sebekova, K., Sebekova Jr, K., Heidland, A., and Thornalley, P.J. (2005) Effect of bilateral nephrectomy and ureteral ligation on circulating levels of advanced glycation end products in the rat. J. Amer. Soc. Nephrol. 16, 803A.

105. Thornalley, P.J., Schupp, N., Ahmed, N., Braun, J., Vienken, J., Stopper, H., and Heidland, A. (2005) Protein glycation, oxidation and nitration residues in plasma proteins and free adducts in uremia: Effect of hemodiafiltration and hemodialysis. J. Amer. Soc. Nephrol. 16, 861A.

106. Thornalley, P.J., Johal, C., Dobler, D., Babaei-Jadidi, R., and Ahmed, N. (2005) Concentrations of glucose degradation products, glyoxal, methylglyoxal and 3-deoxyglucosone, in current generation peritoneal dialysis fluids determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). J. Amer. Soc. Nephrol. 16, 268A.

107. Dawnay A, Agalou S, Ahmed N, Thornalley PJ (2005) Accumulation of advanced glycation free adducts in mild chronic renal failure. Nephrology 10: A20-A20

108. Babaei-Jadidi, R., Al-Ali, H., Ahmed, N., Song, L., Ahmed, A., Bodmer, C. and Thornalley, P.J. (2006) Plasma thiamine deficiency in type 1 and type 2 diabetic patients in the United Kingdom with and without microalbuminuria. Diabetic Med. 23 (Suppl. 2), 48. WINNER OF ELI LILLY CLINICAL SCIENCE POSTER AWARD

109. Dobler, D. and Thornalley, P.J. (2006). Angiogenesis inhibited by extracellular matrix glycation by methylglyoxal. Diabetic Med. 23 (Suppl. 2), 40.

110. Ahmed, N., Ahmed, U., Thornalley, P.J., Watts, R., Tarr, J., Haigh, R. and Winyard, P. (2006) Profound increase in proteolytic products of glycated and oxidised proteins in synovial fluid and plasma in osteoarthritis and rheumatoid arthritis, corrected by TNF-α antibody therapy in rheumatoid arthritis. Rheumatology 45, Suppl. 1, i53.

111. Qian, Q., Babaei-Jadidi, R., Ahmed, N and Thornalley, P.J. (2006) Reversal of biochemical dysfunction in endothelial cells in hyperglycemia by induction of antioxidant response element-linked gene expression by sulforaphane. Diabetes 55, Suppl. 1, A184-A185.

112. Bierhaus, A., Stoyanov, S., Haag, G.-M., Konrade, I., Thornalley, P.J., Thorpe, S.R., Nawroth, P.P. (2006) RAGE-deficiency reduces Diabetes-associated Impairment of glyoxalase-1 in neuronal cells. Diabetes 55, Suppl. 1, A511.

113. Konrade, I., Stoyanov, Haag, G.-M., Seregin, Y., Humpert, P.M., Morcos, M., Thorpe, S.R., Thornalley, P.J., Nawroth, P.P. and Bierhaus, A., (2006) RAGE-dependent impairment of glyoxalase-1 contributes to functional deficits in diabetic neuropathy. Diabetolgia 49, Suppl. 1, 662.

114. Imbasi, P. and Thornalley, P.J. (2006) Decreased endogenous and hydrogen peroxide-induced reactive oxygen species in HepG2 cells by dietary isothiocyanates. Free Radical Res. 40, Suppl. 1, S95-S95.

115. Carpenter, S.J., Nateri, A.S., Stanway, G. and Thornalley, P.J. (2006) Glyoxalase 1 and multidrug resistance in cancer chemotherapy. Proc Natl Cancer Res. Inst.

116. Dobler, D. and Thornalley, P.J. (2006) Glyoxalase 1 – a novel target for anti-angiogenesis cancer chemotherapy. Proc Natl Cancer Res. Inst.

117. Ndoni, S.A., Babaei-Jadidi, R., Roper, D., Wild, B.J., Vulliamy, T.J., Thornalley, P.J. and Layton, M. (2006) A novel therapeutic approach in triosephosphate isomerase deficiency Blood 108, 11.

118. Antonysunil, A.K., Muthuswamy, B., Radhakrishnan, R., Raj, D., Thornalley, P.J. and Viswanathan, M. (2007) Telomere shortening in subjects with impaired glucose tolerance and patients with diabetic macroangiopathy. Comp. Biochem. Physiol. 146A, S59.

119. Antonysunil, A.K., Muthuswamy, B., Radhakrishnan, R., Raj, D., Thornalley, P.J. and Viswanathan, M. (2007) Telomere shortening in subjects with impaired glucose tolerance and patients with diabetic macroangiopathy. Comp. Biochem. Physiol. 146A, S63 – S64. YOUNG SCIENTIST AWARD SESSION

120. Xue, M.Z. and Thornalley, P.J. (2007) Sulforaphane suppresses reactive oxygen species and induces transcriptional activation of antioxidant response element related genes expression in human BJ-5ta fibroblasts. Comp. Biochem. Physiol. 146A, S55 – S56.

121. Thornalley, P.J. (2007) Glycation and the enzymatic defence against glycation in the ageing process. Comp. Biochem. Physiol. 146A, S57.

122. Morcos, M., Du, X., Sayed, A.A.R., Hutter, H, Pfisterer, F., Kukudov, G., Thornalley, P.J., Baynes, J., Thorpe, S., Abd El Baki, R., Rabbani, N., Stern, D., Schlotterer, A., Möhrlen, F., Humpert, P., Hammes, H.P., Büchler, M., Bierhaus, A., Brownlee, M., Nawroth, P.P. (2007) Life extension in Caenorhabditis elegans by overexpression of Glyoxalase I – a mechanistic integration of protein damage by glycation, oxidation and nitration. Comp. Biochem. Physiol. 146A, S59.

123. Antonysunil, A.K., Babaei-Jadidi, R., Rabbani, N., Ahmed, A., Rayman, G., Bodmer, C.W. and  Thornalley, P.J. (2007) Increased Thiamine Transporter Contents of Red Blood Cells and Peripheral Blood Mononuclear Leukocytes in Type 1 and Type 2 Diabetic Patients. Diabetes 56, A609.

124. Rabbani, N. and Thornalley, P.J. (2007) Quantitation of glycation adducts in HDL by liquid chromatography with tandem mass spectrometric detection. Atherosclerosis 8, Suppl 1, 35.

125. Dobler, D., Rabbani, N. and Thornalley, P.J.  (2007) Functional impairment of type IV collagen by arginine-directed and not by lysine- directed advanced glycation. http://dfa.leb.chemie.tu-muenchen.de/maillard/ismr9_program_index, BM35

126. Carpenter, S.J., Nateri, A.S., Stanway, G. and Thornalley, P.J. (2007) Glyoxalase 1 and multidrug resistance in cancer chemotherapy – role for dicarbonyl glycation in cancer chemotherapy and the enzymatic defence against glycation in multidrug resistance. Ann. http://dfa.leb.chemie.tu-muenchen.de/maillard/ismr9_program_index, BM36

127. Rabbani, N., Dobler, D., and Thornalley, P.J. (2007) Improved assay methodology for assay of dicarbonyls in physiological systems using LC-MS/MS with isotopomer internal standardisation. http://dfa.leb.chemie.tu-muenchen.de/maillard/ismr9_program_index, BM24

128. Perkins, B., Rabbani, N., Weston, A., Adaikalakoteswari, A., Ficociello, L., Warram, J., Krolewski, A.S., Thornalley, P.J. (2008) Early Renal Function Decline in Type 1 Diabetes is Associated with Excess Urinary Excretion of Markers of Protein Damage. Diabetes 57, A210-A210

129. Antonysunil, A., Perkins, B., Krolewski, A., Rabbani, N., Thornalley, P.J. (2008) Thiamine status and risk of early renal function decline in type 1 diabetic patients. Diabetologia 51, S98-S98   

130. Rabbani, N. and Thornalley, P.J. (2008) Increased protein damage by advanced glycation endproducts and oxidation adducts in low density lipoprotein of type 2 diabetic patients. Diabetologia 51, S525-S525.

131. Xue, M., Thornalley, P.J. and Rabbani, N. (2008) LDL glycated by methylglyoxal to physiological extent in vitro has increased binding of proteoglycan without impairment of LDL receptor binding. Diabetologia 51, S299-S299.

132. Larkin, J.R. and Thornalley, P.J. (2008) High glucose causes a decrease in expression of thiamine transporters in human proximal tubule epithelial cells in vitro. Diabetologia 51, S97-S97.

133. Kihm, L.R., Muller-Krebs, S., Ehrlich, G., Gross, M.-L., Thornalley, P.J., Zeier, M. and Schwenger, V. (2008) Benfotiamine prevents peritoneal damage in a PD model in uremic rats. J. Amer Soc Nephrol. 19, Suppl 1, 80A.

134. Klooster, A.,   Leuvenink, H.G.D., Gans, R.O.B., van Goor, H., Thornalley, P.J., Navis, G. and Bakker, S.J.L. (2008) Thiamine deficiency amerliorates renal ischaemia- reperfusion injury: role for impaired macrophage accumulation? J. Amer Soc Nephrol. 19, Suppl 1, 167A.

135. Karachalias, N., Babaei-Jadidi, R., Rabbani, N., and Thornalley, P.J. (2009) Prevention of advanced glycation endproduct accumulation in renal glomeruli, retina and nerve in experimental diabetes by high dose thiamine and Benfotiamine. Diabetic Medicine, 26 (Suppl. 1), 70.

136. Yamada-Fowler, N., Godfrey, L., Thornalley, P.J. and Rabbani, N. (2009) Quantitation of the glycation-induced changes in HDL2 and HDL3 by liquid chromatography with tandem mass spectrometric detection. Diabetic Medicine, 26 (Suppl. 1), 70.

137. Thornalley, P., Xue, M., Rabbani, N. (2009) Involvement of transcription factor nrf2 and antioxidant response element linked gene expression in countering oxidative stress in diabetes. FEBS Journal 276, 79 – 80.

138. Stoyanov, S.B., Fleming, T., Humpert, P.M., Sauer, S., Rabbani, N., Edelstein, D., Thornalley, P.J., Reeh, P., Brownlee, M., Nawroth, P.P. and Bierhaus, A. (2009) Loss of glyoxalase-1 promotes hyperalgesia in early diabetic neuropathy. Diabetologia 52, 1146.

139. Rabbani, N., Chittari, M.V., Zehnder, D., Ceriello, A. and Thornalley, P.J. (2009) High dose metformin therapy reduces glycation and oxidative damage to apolipoprotein B100 and may decelerate atherosclerosis in patients with type 2 diabetes. Diabetologia 52,  1293.

140. Riaz, S., Alam, S.S., Rabbani, N., Thornalley, P.J. and Akhtar, W. (2009) Study of protein biomarker for diabetes type 2 and role of thiamine on their levels. Journal of Physiological Sciences 59, Suppl. 1, 506-506.   

141. Karachalias, N., Babaei-Jadidi, R., Rabbani, N. and Thornalley, P.J. (2010) Prevention of decline in glycaemic control in streptozotocin-induced diabetic rats by thiamine but not by Benfotiamine. Diabetic Med. 27, Suppl 1, 74.

142. Ahmed, U., Rabbani, N., Filer, A., Watts, R., Raza, K., and Thornalley, P. (2010) Changes in Advanced Glycation Endproducts in Synovial Fluid in Early Resolving Arthritis and Early and Established Rheumatoid Arthritis. Rheumatology 49, I161

143. Godfrey, L., Thornalley, P.J. and Rabbani, N. (2011) Mimicking the pro-atherogenic phenotype of diabetic dyslipidaemia – glycation by methylglyoxal decreases particle size of HDL2. Diabetic Med. 28, Suppl. 1, 63

144. Rabbani, N., Godfrey, L. and Thornalley, P.J. (2011) Atherogenic transformation of LDL by glycation with methylglyoxal – reduction of particle size and increase binding to the aorta in vivo. Diabetic Med. 28 (Suppl. 1), 63

145. Ahmed, U., Rabbani, N., Costa, M., Watts, R. and Thornalley, P.J. (2011) Increasing concentrations of proteolytic debris of glycated and oxidised proteins in patients with increasing severity of osteoarthritis. Journal of Bone & Joint Surgery  93-B,  Supp  I,  70

146. Zhang, F., Larkin, J., Godfrey, L., Rabbani, N. and Thornalley, P.J. (2011) Intensive insulin therapy attenuates renal thiamine mishandling in streptozotocin-induced diabetic rats. Diabetic Med. 28 (Suppl. 1), 63 – 64

147. Ajjan, R.A., Gamlen, T., Standeven, K.F., Mughal, S., Hess, K., Phoenix, F,  Anwar, M.M., Rabbani, N., Thornalley, P.J., Philippou, H. and Grant, P.J. (2011) Fructosamine-modified plasminogen in diabetes reversibly inhibits fibrinolysis by reducing plasminogen-fibrin interactions and altering plasmin specific activity. Diabetes 28 (Suppl. 1), A144, 

148. Rabbani, N., Godfrey, L., Xue, M. and Thornalley, P.J. (2011) Conversion of low density lipoprotein to the small, dense pro-atherogenic form by glycation with methylglyoxal. Diabetes 28 (Suppl. 1), A157, 

149. Larkin, J.R., Rabbani, N., Zehnder, D. and Thornalley, D.J. (2011) Down regulation of thiamine transporter expression in human tubular epithelial cells in vitro and increased thiamine clearance in diabetes. Diabetes 28 (Suppl. 1), A1.

150. Jerums, G, Panagiotopoulos, S., MacIsaac, R.J., Yue, D.K., Fulcher, G.R., Roberts, M., Larkin, J.R., Adaikalakoteswari, A., Rabbani, N. and Thornalley, P.J. (2011) Circulating markers of protein glycation, oxidation and nitration in type 2 diabetes and effect of decline in renal function. Diabetes 28 (Suppl. 1), A166.

151. Ahmed, U., Costa, M.,Watts, R., Thornalley, P.J., and Rabbani, N. (2011) Increased citrullinated protein in synovial fluid and serum of early and advanced osteoarthritis. BORS, in press.

152. Ahmed, U., Filer, A., Raza, K., Thornalley, P.J., and Rabbani, N. (2011) Measurement of citrullinated protein in early rheumatoid arthritis and non-specific synovitis by liquid chromatography-tandem mass spectrometry. BORS, in press. 

153. Rabbani, N., Adaikalakoteswari, A., Rossing, K., Rossing, P., Parving, H.-H. and Thornalley, P.J. (2011) Glycosylation gap is influenced by Irbesartan treatment in patients with type 2 diabetes and microalbuminuria. Diabetologia 54, Suppl. 1, S444.

154. Larkin, J.R., Rabbani, N., Zehnder D., Thornalley, P.J. (2011) Down regulation of thiamine transporter expression in human tubular epithelial cells by high glucose concentration in vitro and increased thiamine clearance in diabetes.  www.britishrenal.org/Abstracts/

155. Rabbani, N. and Thornalley, P.J. (2011) The pro-atherogenic phenotype in ageing – lipoprotein B100 and A1 leading the dance into decline of vascular health by oxidative and non-oxidative mechanisms. Rejuvenation Res. http://www.sens.org/node/2139

156. Xue, M., Rabbani, N. and Thornalley, P.J. (2011) Decline of the nuclear factor E2-related factor 2 (nrf2) and antistress gene response in ageing and strategies to prevent it for healthy ageing. Rejuvenation Res. http://www.sens.org/node/2140

157. Thornalley, P.J. and Rabbani, N. (2011) Increased damage to proteins in ageing – wear and tear potentially avoidable by extending preventive maintenance of life’s essential machinery. Rejuvenation Res. http://www.sens.org/node/2138

158. Thornalley, P.J. and Rabbani, N. (2011) Glycation by methylglyoxal in physiological systems – the damage caused and strategies to prevent it. Amino Acids 41 (Suppl 1), S11.

159. Rabbani, N. and Thornalley, P.J. (2011) Atherogenic transformation of LDL and impaired function of HDL by glycation.  Amino Acids 41 (Suppl 1), S8.

160. Thornalley, P.J., Xue, M. and Rabbani, N. and (2011) Role of nrf2 and the antistress gene response in countering oxidative stress in diabetes mellitus. Clinical Chemistry And Laboratory Medicine 49, S52-S52

161. Lopez-Clavijo, A.F., Rabbani, N., Thornalley, P.J. and O’Connor, P. (2011) Binding site identification of glyoxal in peptides by ECD and CAD using FT-ICR-MS. http://www.bmss.org.uk/Docs/BMSS%20Meeting%20-%20Posters%205.8.11.pdf

162. Xue, M., Momiji, H., Rabbani, N., Barker, G., Rand, D.A. and Thornalley, P.J. (2012) Control of ARE-linked gene expression by cytoplasm-nucleus translocational oscillations of Nrf2. Free Radical Biology and Medicine 53, Supp 1,  S37.

163. Xue, M., Momiji, H., Rabbani, N., Barker, G., Rand, D.A. and Thornalley, P.J. (2012)   Multi-tiered protective response of Nrf2 transactivational activity in endothelial cells in vitro. Free Radical Biology and Medicine 53, Supp 1, S233.

164. Xue, M., Momiji, H., Rabbani, N., Barker, G., Rand, D.A. and Thornalley, P.J. (2012)   Effect of Nrf2 activators on protein oxidative damage in human endothelial cells in vitro. Free Radical Biology and Medicine 53, Supp 1, S100.

165. Hariton, F., Xue, M., Rabbani, N. and Thornalley, P.J. (2012) Protective response of Nrf2 transactivational activity in MRC-5 fibroblasts in vitro. Free Radical Biology and Medicine 53, Supp 1, S80.

166. Shaheen, F., Wilkinson, D., Rabbani, N. and Thornalley, P.J. (2012) A new sensitive liquid chromatography-tandem mass spectrometry technique to measure 3-nitrotyrosine. Free Radical Biology and Medicine 53, Supp 1, S188.

167. Ahmed, U., Raza, K., Watts, R., Thornalley, P.J. and Rabbani, N. (2012) Oxidative biomarkers increase in patients with increasing severity of rheumatoid arthritis. Free Radical Biology and Medicine 53, Supp 1, S165-S166.

168. Ahmed, U., M.L., Watts, R., Thornalley, P.J. and Rabbani, N. (2012) Oxidative biomarkers increase in patients with increasing severity of osteoarthritis. Free Radical Biology and Medicine 53, Supp 1, s168-s169

169. Zhang, F., Evans, N.D., Larkin, J.R.,  Godfrey, L.,  Yamada-Fowler, N.,  Chappell, M.J., Rabbani, N. and  Thornalley, P.J. (2013) Pharmacokinetics of thiamine in streptozotocin-induced diabetic rats reveals thiamine mishandling in the kidney, retina and peripheral nerve exposing these tissues to increased risk of thiamine deficiency. Diabetic Medicine 30, S1, 67.

170. Masania, J. Thornalley, P.J. and Rabbani,N. (2013) reading the patterns of endogenous damage to the proteins, Annals of Nutrition and Metabolism, 63, 9.

171. Masania, J., Rabbani, N, Klaus, S., Thornalley, P.J. Ost, M. and Keipert, S. (2013) Decreased methylglyoxal-modified protein damage in the HSA-UCP1 mouse model of healthy ageing. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P035.pdf

172. Anwar, A., Shaheen, F., Tym, A.E., Masania, J., Rabbani, N. and Thornalley, P.J. (2013) Stable isotopic dilution analysis of AGEs and amino acids metabolome by liquid chromatography-tandem mass spectrometry. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P037.pdf

173. Tym, A.E., Jin, T., Rabbani, N., Rossmeisl, M., Kopecky, J., Squires, P. and Thornalley, P.J. (2013) Dicarbonyl stress and beta-cell dysfunction. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P041.pdf

174. Ahmed, U., Anwar, A., Costa, M., Watts, R., Thornalley, P.J. and Rabbani, N. (2013) Methylglyoxal and glyoxal derived protein damage markers in diagnosis and progression of osteoarthritis. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P009.pdf

175. Shaheen, F., Shymygol, A., Rabbani, N. and Thornalley, P.J.  (2013) A fluorogenic assay for methylglyoxal. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P012.pdf

176. Rabbani, N., Godfrey L., Yamada-Fowler, N., Smith, J. and  Thornalley, P.J. (2013) Methylglyoxal modification is a major factor linked to decreased plasma concentration and functionality of HDL. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P027.pdf

177. Shafie, A., Xue, X., Rabbani, N. and Thornalley, P.J. (2013) Difficulties in generating a Glo1 mutant mouse. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P028.pdf

178. Waris, S., Winklhofer-Roob, B.M., Roob, J.M., Fuchs, S., Sourij, H., Rabbani, N. and Thornalley, P.J. (2013) Increased dicarbonyl glycation and oxidation adducts of deoxyguanosine in plasma and urine of patients with type 2 diabetes and link to diabetic nephropathy. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P030.pdf

179. Ashour, A.A., Thornalley, P.J. and Rabbani, N. (2013) Dicarbonyl stress and the glyoxalase system in periodontal ligament fibroblasts in vitro. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P031.pdf

180. Hariton, F.A.G., Xue, M., Rabbani, N. and Thornalley, P.J. (2013) Dicarbonyl stress and the glyoxalase system in fibroblast senescence in vitro. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P032.pdf

181. Arai, M., Rabbani, N., Itokawa, M. and Thornalley, P.J.(2013) Glyoxalase activity and dicarbonyl stress in human cell lines of neurological origin. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P033.pdf

182. Irshad, Z., Thornalley, P.J. and Rabbani, N. (2013) Disturbance of the glyoxalase system in human vascular endothelial cells by high glucose in vitro. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P034.pdf

183. Shaheen, F., Rabbani, N. and Thornalley, P.J. (2013) Glyoxalase 1 copy number variation and its effect on dicarbonyl metabolism. Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P042.pdf

184. Walley, P.G., Rabbani, N. and Thornalley, P.J. (2013) Methylglyoxal concentration in cotyledons and mature leaves of broccoli (Brassica oleracea L var. italica). Biochem. Soc. Trans. http://www.biochemistry.org/Portals/0/Conferences/abstracts/SA158/SA158P046.pdf

185. Ashour, A., Thornalley, P.J. and Rabbani, N. (2014) Decrease glyoxalase 1 activity increases dicarbonyl stress in periodontal ligament fibroblasts in model hyperglycaemia. Diabetes 63, Suppl. 1, A492.

186. Tym, A., Jin, T., Rossmeisl, M., Kopecky, J., Squires, P., Rabbani, N. and Thornalley, P.J. (2014) Increased pancreatic methylglyoxal in insulin resistance and beta cell detachment from the extracellular matrix. Diabetes 63, Suppl. 1, A553 – A554.

187. Rabbani, N., Godfrey, L., Yamada-Fowler, N., Smith, J. and Thornalley, P.J.  (2014) Methylglyoxal derived AGEs increase in HDL isolated from patients with diabetes and increased insulin resistance. Diabetes 63, Suppl. 1, A111

188. Irshad, Z., Xue, M., Thornalley, P.J. and Rabbani, N. (2014) Disturbance of the glyoxalase system in human vascular endothelial cells by high glucose in vitro and reversal by trans-resveratrol. Diabetes 63, Suppl. 1, A9

189. Shafie, A., Xue, M., Thornalley, P.J. and Rabbani, N. (2014) Evaluation of a glyoxalase 1 mutant mouse. Diabetologia 57, Suppl. 1, S528.

190. Rabbani, N., Godfrey, L., Yamada-Fowler, N., Smith, J. and Thornalley, P.J. (2014) One-compartment kinetic model predicts dicarbonyl modification influence half-life and functionality of HDL in high risk CVD group. Diabetologia 57, S529.

191. Thornalley, P.J., Irshad, Z., Xue, M. and Rabbani, N. (2014) Metabolic modelling of methylglyoxal formation, metabolism and AGE formation in vascular endothelial cells in model hyperglycemia in vitro. Diabetologia 57, Suppl. 1, S34 – S35.

192. van Schothorst, E.M., Duivenvoorde, L., Derous, D., van der Stelt, I., Masania, J., Rabbani, N., Thornalley, P.J.,  and  Keijer, J. (2014) Oxygen restriction as challenge test reveals early diet-induced health effects. Diabetologia 57, Suppl. 1, S232.

193. Arai, M., Miyashita, M., Kobori, A., Toriumi, K., Horiuchi, Y., Rabbani, N., Thornalley, P. and Itokawa, M. (2014) Idiopathic carbonyl stress in a subpopulation of schizophrenia. Early Intervention in Psychiatry 8, 36 – 36.

194. Arai, M., Miyashita, M., Kobori, A., Toriumi, K., Horiuchi, Y., Rabbani, N., Thornalley, P.J. and Itokawa, M. (2014) Research on dicarbonyl accumulation and AGEs formation in schizophrenia. Early Intervention in Psychiatry 8, 98 – 98.

195. Rabbani, N. and Thornalley, P.J. (2015) Methylglyoxal modification of low density lipoprotein – a novel route to the pro-atherogenic, small dense LDL with increased arterial proteoglycan binding and aortal retention. Atherosclerosis 241, e56.

196. Xue, M., Momiji, H., Rabbani, R., Barker, G., Shmygol, A., Bretschneider, T., Rand, D.A. and Thornalley, P.J. (2015) Antioxidant response element cytoprotective response in aortic endothelial cells coordinated by transcription factor Nrf2 is regulated through frequency-modulated translocational oscillations. Atherosclerosis 241, e2.

197. Rabbani, N. and Thornalley, P.J. (2015) Arginine-directed glycation by methylglyoxal is a factor decreasing HDL plasma concentration and functionality in vivo. Atherosclerosis 241, e33.

198. Maldonado, E.M., Rabbani, N., Thornalley, P.J., Wang, H., Miller, M., Dillon, J.F. and Moore, J.B. (2015) Examination of methylglyoxal levels in an in vitro model of steatosis and serum from patients with non-alcoholic fatty liver disease. Proceedings of the Nutrition Society 74, E1.

199. Rabbani, N. and Thornalley, P.J. (2016) Physiological glycation by methylglyoxal, glyoxalase 1 and developments in disease mechanisms and clinical therapeutics. The FEBS Journal 283 (Suppl. 1) 12–54.

200. Rabbani, N., Xue, M., Weickert, M.O., Qureshi, S., Kandala, N.-B., Anwar, A., Waldron, M., Shafie, A. and Thornalley, P.J. (2016) Discrimination between advanced glycation endproducts of endogenous and dietary origin in overweight and obese non-diabetic subjects. Diabetologia. 59, S535 – S536.

201. Shafie, A., Xue, M., Thornalley, P.J. and Rabbani, N. (2016) Dicarbonyl stress induces glyoxalase 1 copy number increase in mouse embryonic stem cells in vitro and escapes mutation lethality in gene trapping. Diabetologia 59, S525 – S526.

202. Xue, M., Weickert, M.O., Qureshi, Q., Kandala, N.-B., Anwar, A., Waldron, M., Shafie, A., Rabbani, N. and Thornalley, P.J. (2016) An inducer of glyoxalase 1 down regulates inflammatory gene expression in overweight and obese non-diabetic subjects. Diabetologia 59, S300.

203. Thornalley, P.J., Xue, M., Weickert, M.O., Qureshi, Q., Kandala, N.-B., Anwar, A., Waldron, M., Shafie, A. and Rabbani, N. (2016) An inducer of glyoxalase 1 improves insulin resistance and glycaemic control in overweight and obese non-diabetic subjects. Diabetologia 59, S141 – S142.

204. Ashour, A., Thornalley, P.J., and Rabbani, N. (2016) A glyoxalase 1 inducer protects human periodontal ligament fibroblasts from dicarbonyl stress and dysfunction in model hyperglycaemia in vitro. Diabetologia 59, S522.

205. Xue, M., Weickert, M.O., Rabbani, N. and Thornalley, P.J. (2017) Glyoxalase-1 inducer treatment in obesity correlates with improved glycemic control, vascular inflammation, and dyslipidemia. Diabetes 66 (Supplement 1), A334.

206. Rabbani, N., Xue, M., Weickert, M.O. and Thornalley, P.J. (2017) Endogenous and dietary contributions to advanced glycation endproducts. Diabetes. 66 (Supplement 1), A562

207. Ashour, A., Thornalley, P.J., and Rabbani, N. (2017) Impaired adhesion of human periodontal ligament fibroblast to collagen-I in model hyperglycaemia in vitro is corrected by Glo1inducer. Diabetologia 60 (Suppl. 1), S558.

208. Thornalley, P.J., Ashour, A., Irshad, Z., and Rabbani, N. (2017) Disturbance of the cytosolic proteome in human aortal endothelial cells in high glucose concentration in vitro Diabetologia 60 (Suppl. 1), S539

209. Rabbani, N., Ashour, A., Pasha, S., Shafie, A. and Thornalley, P.J. (2017) Glyoxalase-1 inducer corrects down regulated cytosolic proteome in periodontal ligament fibroblasts in model hyperglycaemia. Diabetologia 60 (Suppl. 1), S558 – S559.

210. Ahmed, U., Thornalley, P.J., and Rabbani, N. (2017) Two-step algorithm for early diagnosis of osteoarthritis based on plasma damaged amino acids provides simple and low cost screening test. Ann Rheumatic Dis. 76, Suppl. 2, 1025-1025

211. Ahmed, U., Thornalley, P.J., and Rabbani, N. (2017) Increased protein glycation, oxidation and nitration with increasing severity of rheumatoid arthritis in a cross-sectional study assessed by robust stable isotopic dilution analysis quantitation. Rheumatology 56, suppl. 2, ii125.

212. Ahmed, U., Thornalley, P.J., and Rabbani, N. (2017) Protein oxidation, nitration and glycation free adducts biomarkers for early-stage diagnosis and typing of arthritis. Rheumatology 56, suppl. 2, 163-164.

213. Ahmed, U., Lambert, C., Legrand, C., Anwar, A., Rajpoot, K., Pasha, S., Davidson, R., Clark, I., Thornalley, P., Rabbani, N. and Henrotin, Y. (2018) Glucosepane: a new biomarker of the severity of osteoarthritis. Osteoarthritis & Cartilage 26, Suppl. 1, S181. 

214. Thornalley, P.J., Irshad, Z., Xue, M., Ashour, A. and Rabbani, N. (2018) Increased hexokinase-2-catalysed entry of glucose into glycolysis – key driver of metabolic dysfunction in endothelial cells in hyperglycemia. Diabetologia 61, Suppl 1, S68.

215. Rabbani, N. Irshad, Z., Xue, M., Ashour, A. and Thornalley, P.J. (2018) Methylglyoxal driven endothelial dysfunction in hyperglycemia targets protein folding, protein synthesis, glycolysis and gluconeogenesis pathways. Diabetologia 61, Suppl 1, S68.

216. Xue, M., Irshad, Z., Ashour, A. and Thornalley, P.J. and Rabbani, N. (2018) Increased methylglyoxal protein modification in hyperglycemia induces an inflammatory phenotype in endothelial cells in hyperglycemia by activation of the unfolded protein response. Diabetologia 61, Suppl 1, S546.

217. Abbas, H., Xue, M., Rabbani, N. and Thornalley, P.J. (2018) Glyoxalase 1 overexpression associated multidrug resistance in cancer chemotherapy. Brit. J Cancer 19, 47.

218. Thornalley, P.J., Xue, M., Ashour, M. and Rabbani, N. (2019) Combination of trans-resveratrol and hesperetin corrects unscheduled increased glucose metabolism driving endothelial cell dysfunction in hyperglycemia in vitro. Diabetes 68, suppl. 1, 485

219. Ashour, M., Rabbani, N. Thornalley, P.J. and Xue, M. (2019) Combination Of Trans-Resveratrol And Hesperetin Corrects Unscheduled Increased Glucose Metabolism Driving Dysfunction Of Human Periodontal Ligament Fibroblasts In Hyperglycemia In Vitro. Diabetes, 68, Suppl. 1, 479.

220. Thornalley, P.J. (2019) Physiological glycation by glucose and reactive dicarbonyl metabolite, methylglyoxal – targets, hotspots & engagement with the unfolded protein response. Glycoconj. J. 36, 270 – 271.

221. Al-Motawa, M.S., Rabbani, N. and Thornalley, P.J. (2020) Use of protein informatics to assess how mutations of glucokinase affect enzymatic function. Diabetologia 63, Suppl. 1, S153.

222. Thornalley, P.J., Xue, M., Weston, K., Ali Alsiddig, R., Diane, A., Abdalhakam, I., Alkasem, M., Shraim, M., Rustom, H., Hashish, A., Dehbi, M. and Young-Skarulis, M. (2020) Dicarbonyl stress marker, D-Lactate, correlates with hyperinsulinemic-euglycemic clamp measure of insulin resistance in overweight and obese subjects with type 2 diabetes. Diabetologia 63, Suppl. 1, S225 – S226.

223. Xue, M., Weickert, M.O., Rabbani, N. and Thornalley, P.J. (2021) Reversal of insulin resistance by resveratrol and hesperetin combination in overweight and obese subjects correlates with decrease in expression of thioredoxin interacting protein. Diabetes 70, Suppl. 1, 338-OR.

224. Rabbani, N., de la Fuente, A. and Thornalley, P.J. (2021) Risk prediction of early decline in renal function in diabetic kidney disease with algorithm including fractional excretion of glycated amino acids. Diabetes 70, Suppl. 1, 186-OR.

225. Thornalley, P.J., Xue, M. and Rabbani, N. (2021) Dynamics of hexokinase-2 linked glycolytic overload mediating endothelial cell dysfunction in high glucose concentration in vitro. Diabetologia 64, Suppl. 1, 331.

226. Abbas, H., Xue, M., Rabbani, N. and Thornalley, P.J. (2021) Glyoxalase 1 – a multidrug resistance factor in cancer chemotherapy. IMARS Highlights 16 (6), 96.

227. de la Fuente, A., Rabbani, N. and Thornalley, P.J. (2021) Risk prediction of early decline in renal function in diabetic kidney disease with an algorithm including fractional excretion of glycated amino acids. IMARS Highlights 16 (6), 99.

228. Xue, M., Rabbani, N. and Thornalley, P.J. (2021) Dicarbonyl stress increases expression of thioredoxin interacting protein and CHOP linked to the NLRP3 Inflammasome in human aortal endothelial cell in vitro. IMARS Highlights 16 (6), 101.

229. Al-ali, A.S., Qidwai, U., Fetais, N., Thornalley, P.J. and Naila Rabbani, N. (2021) ANFIS classifier for early diagnosis of autistic spectrum disorder based on plasma amino acid metabolome biomarkers. IMARS Highlights 16 (6), 104.

230. Jabbar, R., Said, A.B., Fetais, N., Rabbani, N. and Thornalley, P.J. (2021) Machine-learning-based prediction models for early-stage diagnosis of knee osteoarthritis‏ using protein oxidation, nitration and glycation biomarkers. IMARS Highlights 16 (6), 105.

231. Rabbani, N., Xue, M., Weickert, M.O. and Thornalley, P.J. (2021) Urinary glucosepane as a marker of glycemic control in non-diabetic subjects – insight from the HATFF study. IMARS Highlights 16 (6), 110.

232. Elbashir, I., Al-Saei, A.N.J.M.A-S., Thornalley, P.J. and Rabbani, N. (2021) Evaluation of antiviral activity of Manuka honey against SARS-CoV-2. IMARS Highlights 16 (6), 122.

233. Al-Motawa, M., Rabbani, N. and Thornalley, P.J. (2021) Genetics of glycation – glycated hemoglobin, GLO1 single nucleotide polymorphisms and copy number variation. IMARS Highlights 16 (6), 35.

234. Alhujaily, M., Xue, M., de la Fuente, A., Rabbani, N., and Thornalley, P.J. (2021) The spliceosome is a target for glycation in methylglyoxal-induced apoptosis and is shielded by glyoxalase 1 in multidrug resistance-linked cancer chemotherapy. IMARS Highlights 16 (6), 57.

235. Xue, M, Rabbani, N. and Thornalley, P.J. (2021) Anti-inflammatory activity of glyoxalase-1 inducer, trans-resveratrol and hesperetin, in human small airway epithelial cell primary cultures support application for prevention of COVID-19. IMARS Highlights 16 (6), 51.

236. Alhujaily, M., Abbas, H., Xue, M., de la Fuente, A., Rabbani, N. and Thornalley, P.J.  (2021) Methylglyoxal is a common contributor and glyoxalase 1 a negative survival factor in cancer chemotherapy, respectively targeting and shielding the spliceosome. Clin Cancer Invest J

237. Xue, M., Rabbani, N. and Thornalley, P.J.  (2022) Anti-inflammatory activity of glyoxalase-1 inducer supports further evaluation for prevention of COVID-19. Diabetes Res. Clin. Pract. 186, Suppl. 1, 109325.

238. AlKhatib, H.A.M., Elbashir, I., Yassine, H. and Thornalley, P.J. and Rabbani, N. (2021) Antiviral activity of glucose-derived reactive metabolite, methylglyoxal against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). J Emerg Med Trauma & Acute Care 2022, 8.

239. Xue, M., Al-Motawa, M., Rabbani, N. and Thornalley, P.J.  (2022) Hexokinase-2 linked glycolytic overload – key initiating driver of the development of diabetic vascular complications. Diabetes Res. Clin. Pract. 186, Suppl. 1, 109255.  

240. Al-Saei, A.N.J.M., El Dine, W.N., Yaseen Al-ali, A.S., Ahmed Qidwai, U., Fetais, N., Thornalley, P.J., Al-Shammari^, A.R. and Rabbani, N. (2022) Validation of diagnostic algorithm of a simple blood test for autism. Qatar University Health.

241. Nejat, S., Menikdiwela, K., Scoggin, S., Dehbi, M., Thornalley, P.J. and Moustaid-Moussa, N. (2022) The Effect of DNAJB3 Deficiency on Metabolic Dysfunctions in Diet-induced Obese Mice. Curr Develop Nutrit 6, Supp 1, 1078.

242. Xue, M., Rabbani, N. and Thornalley, P.J.  (2022) Increase of hexokinase-2 protein without increase of other glycolytic enzymes in myotubes with high glucose concentration supports the hypothesis of hexokinase-2-linked unscheduled glycolysis as a driver of insulin resistance. Diabetes 71, Supp. 1, 206-LB.

243. Xue, M., Rabbani, N. and Thornalley, P.J. (2022) Hexokinase-2 linked scheduled glycolysis as a driver of insulin resistance linked dysglycemia – evidence in the murine C2C12 myotube model in vitro. Diabetologia 65 (Suppl 1), S230.

244. Thornalley, P.J., Xue, M. and Rabbani, N. (2022) High glucose concentration-induced dicarbonyl stress in human aortal endothelial cells activates the unfolded protein response and NLRP3 Inflammasome. Diabetologia 65 (Suppl 1), S425.

245. Rabbani, N., Panagiotopoulos, S., MacIsaac, R.J., Yue, D.K., Fulcher, G.R., Roberts, M.A., Ekinci, E. and Thornalley, P.J. (2022) Advanced glycation endproducts in chronic kidney disease in subjects with and without diabetes – AGEs highly responsive to renal function decline and diabetes. Diabetologia 65 (Suppl 1), S392.

246. Wijten, P., Alsaei, A., Rabbani, N and Thornalley, P.J. (2023) Establishing reference intervals for plasma amino acids and trace level glycated amino acids of healthy subjects in Qatar. J Diabetes Endocrine Practice 6 (2), 78.

247. Xue, M., Rabbani, N. and Thornalley, P.J. (2024) Dicarbonyl Stress Is a Dominant Activator of the Unfolded Protein Response in Hyperglycemia. J Diabetes Endocrine Practice 6 (2), 79.

248. Xue, M., Rabbani, N. and Thornalley, P.J. (2023) Activation of three pathways of the unfolded protein response in endothelial cells by methylglyoxal in hyperglycemia. Diabetes Res. Clin. Pract. 209, Suppl. 1, 111221

249. Al-Motawa, M., Xue., M. and Thornalley, P.J. (2024) Proteomic changes in human mesangial cells in model hyperglycemia in vitro – effect of glyoxalase 1 inducer. Diabetes Res. Clin. Pract. 209, Suppl. 1, 111162
     

250. Al-Motawa, M., Xue., M. and Thornalley, P.J. (2024) Proteomic changes in human proximal tubular epithelial cells in model hyperglycemia in vitro – effect of glyoxalase 1 inducer. Diabetes Res. Clin. Pract. 209, Suppl. 1, 111363

251. Rabbani, N. and Thornalley, P.J. (2024) Hyperglycemia-induced cell damage by circumvention of hexokinase saturation at sites of diabetic vascular complications. Diabetes Res. Clin. Pract. 209, Suppl. 1, 111444.